Spermidine Promotes Cardioprotective Autophagy
نویسندگان
چکیده
منابع مشابه
Spermidine Promotes Cardioprotective Autophagy.
Background Our population is aging—shifting in distribution toward older age—at an unprecedented pace. Based on US population reports, the percentage of people aged >65 years is estimated to increase from 13.4% in 2012 to 19.3% in 2030. And as aging is the greatest risk factor for major life-threatening disorders, including cardiovascular and neurodegenerative diseases, metabolic syndromes, and...
متن کاملAutophagy mediates pharmacological lifespan extension by spermidine and resveratrol
Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced by our groups demonstrates that autophagy is also involved in pharmacological manipulations that increase longevity. Exogen...
متن کاملNew roles for autophagy and spermidine in T cells
The conserved lysosomal degradation pathway autophagy is now recognised as an essential cog in immune function. While functionally widespread in the innate immune system, knowledge of its roles in adaptive immunity is more limited. Although autophagy has been implicated in naïve T cell homeostasis, its requirement in antigen-specific T cells during infection was unknown. Using a murine model wh...
متن کاملThe cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy.
Mitochondrial quality control mechanisms have been implicated in protection against cardiac ischemia-reperfusion (IR) injury. Previously, cloxyquin (5-chloroquinolin-8-ol) was identified via phenotypic screening as a cardioprotective compound. Herein, cloxyquin was identified as a mitochondrial uncoupler in both isolated heart mitochondria and adult cardiomyocytes. Additionally, cardiomyocytes ...
متن کاملSpermidine promotes mating and fertilization efficiency in model organisms
Spermidine is a naturally occurring polyamine involved in multiple biological processes, including DNA metabolism, autophagy and aging. Like other polyamines, spermidine is also indispensable for successful reproduction at several stages. However, a direct influence on the actual fertilization process, i.e., the fusion of an oocyte with a spermatocyte, remains uncertain. To explore this possibi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2017
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.117.310603